Pertussis maternal immunization: narrowing the knowledge gaps on the duration of transferred protective immunity and on vaccination frequency

GAILLARD, M. EMILIA; BOTTERO, DANIELA; ZURITA, MARIA EUGENIA; CARRIQUIRIBORDE, FRANCISCO; AISPURO, PABLO MARTIN; BARTEL, ERIKA; SABATER, DAVID; BRAVO, MARÍA SOL; CASTUMA, CELINA; HOZBOR, DANIELA

Frontiers in Immunology

Frontiers - EPFL - Innovation Square

Lugar: Lausanne; Año: 2017

Maternal safety through pertussis vaccination and subsequent maternal-fetal ?antibody transfer are well documented, but information on infant protection from pertussis by such antibodies and by subsequent vaccinations is scarce. Since mice are used extensively for maternal-vaccination studies, we adopted that model to narrow those gaps in our understanding of maternal pertussis immunization. Accordingly, we vaccinated female mice with commercial acellular pertussis vaccine (aP) and measured offspring protection against B. pertussis challenge and specific-antibody levels with or without revaccination. Maternalimmunization protected the offspring against pertussis, with that immune protection transferred to the offspring lasting for several weeks, as evidenced by a reduction (4-5 logs, p