Interaction between Pharmaceutical Drugs and Polymer-Coated Fe3O4 Magnetic Nanoparticles with Langmuir Monolayers as Cellular Membrane Models

S. N. MOYA BETANCOURT; C. I. CÁMARA; J.S.RIVA

Pharmaceutics

MOLECULAR DIVERSITY PRESERVATION INTERNATIONAL-MDPI

Lugar: Basel; Año: 2023 vol. 15 p. 1 - 15

1999-4923

Surface modification of magnetic nanoparticles (MNPs) has been reported to play a significantrole in determining their interactions with cell membranes. In this research, the interactionsbetween polymer functionalized (chitosan, CHI or diethylamino-ethyl dextran, DEAE-D) Fe3O4MNPs, pharmaceutical drugs and model cell membranes were investigated by Langmuir isothermsand adsorption measurements. In this study, 1,2-distearoyl-sn-glycerol-3-phosphate (DSPA) phospholipid monolayers were used as cell membrane models. Insertion experiments demonstrate that diclofenac (DCFN) is not absorbed at the air–water interface, whereas triflupromazine (TFPZ) has a MIP (maximum insertion pressure) of 35 m Nm􀀀1. The insertion of composites MNPs:TFPZ or DCFN has larger MIP values, indicating that the MNPs are adsorbed on the monolayer with the drugs. An Fe3O4@CHI:DCFN composite presented an MIP of 39 mNm􀀀1 and Fe3O4@DEAE-D:DCFN presented an impressive MIP of 67 m Nm􀀀1. In the case of TFPZ, the enhancement in the MIP values is also evident, being 42 mNm􀀀1 for Fe3O4@CHI:TFPZ and 40 mNm􀀀1 for Fe3O4@DEAE-D:DCFN composite.All MNPs:drugs composites have MIP values greater than commonly accepted membrane pressurevalues, indicating that MNPs:drugs can penetrate a cellular membrane. The fact that the compositeMNPs:drugs present greater MIP values than separated compounds indicates that polymer-coatedMNPs can act as good drug delivery systems.