Bacteria lácticas productoras de vitaminas - Nuevos usos contra la inflamación intestinal, el cáncer y enfermedades neurodegenerativas

LEBLANC, JEAN GUY

Sao Paulo

Congreso; GANEPÃO Update 2021/PreProSim 2021; 2021

It has been shown that Lactic Acid Bacteria (LAB) have the ability to produce bioactive compounds including the water soluble B group vitamins folate, riboflavin and thiamine in a strain dependent manner. Growth media, food matrix and the conditions of the gastrointestinal tract can all affect vitamin production. Wild type strains isolated from a wide range of ecological niches (foods, animals, plants) and genetically modified LAB have been used in order to produce novel foods with elevated vitamin concentrations. These vitamin bioenriched foods, or the vitamin producing strains themselves, have been able to prevent and treat vitamin deficiencies in different laboratory animal models and could be used for human consumption or animal production. Furthermore, other non-nutritional functional properties of vitamin producing LAB have been demonstrated in cell culture and animal models. It has been shown that selected folate, riboflavin and thiamine producing LAB can be used to prevent or treat many physiological disorders such as colitis, mucositis, Parkinson?s Disease, colon and breast cancer in rodent models. These vitamin-producing strains could be used as adjunct treatments against these and other inflammatory diseases through the modulation of the immune response and increasing the well-being of patients without affecting the effectiveness of their primary treatments.