INVESTIGADORES
CHIALVO Dante Renato
artículos
Título:
Modular organization of brain resting state networks in chronic back pain patients
Autor/es:
BALENZUELA P, CHERNOMORETZ A, FRAIMAN D, CIFRE I, SITGES C, MONTOYA P AND CHIALVO DR.
Revista:
Frontiers in Neuroinformatics
Editorial:
Frontiers Foundation
Referencias:
Lugar: Lausanne; Año: 2010 vol. 4 p. 1 - 16
ISSN:
1662-5196
Resumen:
Recent work on functional magnetic resonance imaging large-scale brain networks under resting
conditions demonstrated its potential to evaluate the integrity of brain function under normal
and pathological conditions. A similar approach is used in this work to study a group of chronic
back pain patients and healthy controls to determine the impact of long enduring pain over
brain dynamics. Correlation networks were constructed from the mutual partial correlations of
brain activitys time series selected from ninety regions using a well validated brain parcellation
atlas. The study of the resulting networks revealed an organization of up to six communities
with similar modularity in both groups, but with important differences in the membership of
key communities of frontal and temporal regions. The bulk of these findings were confirmed by
a surprisingly naive analysis based on the pairwise correlations of the strongest and weakest
correlated healthy regions. Beside confirming the brain effects of long enduring pain, these results
provide a framework to study the effect of other chronic conditions over cortical function.