INVESTIGADORES
SOSA ESCUDERO Miguel Angel
artículos
Título:
The effect of the lysosomotropic drug chloroquine on the binding of N-acetyl-β-D-glucosaminidase to mannose-6-phosphate recognizing receptors of rat liver
Autor/es:
SOSA MA; BERTINI F
Revista:
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Editorial:
ACADEMIC PRESS INC ELSEVIER SCIENCE
Referencias:
Año: 1986 vol. 131 p. 634 - 639
ISSN:
0006-291X
Resumen:
The binding of N-acetyl-β-D-glucosaminidase to rat liver receptors was studied in the presenceof chloroquine. The association rate constant was not affected in the presence of the drug, whilethe dissociation rate constant and consequently the equilibrium dissociation binding constantsignificatively decreased. This results may explain effects of chloroquine on lysosomal enzymetransport found in cultured cells by other autors.
