Diamines derivatives with antiparasitic activities

GUILLERMO ROBERTO LABADIE; SEOUNG-R. CHOI; MITCHELL A. AVERY

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Elsevier

Año: 2004 vol. 14 p. 615 - 619

0960-894X

There are a lack of effective chemotherapies for many parasitic diseases. Polyamine pathways have been reported as potential targets for the development of new chemotherapies against parasitic diseases. In the present study, different libraries of substituted diamines totalling 78 compounds have been synthesized on solid support and their activities against malaria and leishmania parasites have been determined. Most active compounds demonstrated submicromolar activities against both organisms and their structure–activity relationships are discussed.