INVESTIGADORES
LABADIE Guillermo Roberto
artículos
Título:
Parallel solution synthesis of lavendustin analogs as antileishmanial agents
Autor/es:
DIEGO GHIANO; PAULO B. CARVALHO; BABU L. TEKWANI; MITCHELL A. AVERY; GUILLERMO R. LABADIE
Revista:
ARKIVOC - ONLINE JOURNAL OF ORGANIC CHEMISTRY
Editorial:
ARKAT USA INC
Referencias:
Lugar: Gainsville; Año: 2011 vol. VII p. 297 - 311
ISSN:
1551-7004
Resumen:
A concise parallel synthesis of 12 lavendustin analogs is described. Starting with differently substituted benzaldehydes, a two-step sequence involving reductive amination and N-benzylation accelerated by microwaves was performed to provide the compounds in excellent yields.
The compounds have been assayed in vitro showing activity against Leishmania donovani, the causative agent of visceral leishmaniasis.
