Dalea genus, chemistry and bioactivity studies

MARIANA PERALTA; M DANIELA SANTI; CABRERA J,; ORTEGA MG

Studies in Natural Products Chemistry

ELSEVIER

Año: 2019; p. 307 - 341

A revision of chemical and biological studies on Dalea genus is presented, since the first chemical report of North American species D. emoryi A. Gray, D. polyadenia F. Heller y D. tinctoria Brandegee in 1978, to the recent studies on the South American species D. pazensis Rusby in 2017. The Natural products isolated from Dalea and their pharmacological activity are introduced. Dalea L. genus comprises 172 species, distributed from Canada to Argentina and Chile, which are found mainly in deserts, grasslands, thorny scrub, tropical dry forest, and tropical mountain forest areas. Ethnobotanical studies reported that North American species were used by native people such as Apache and Dakotas, for different illnesses, like headaches, rheumatism, heart diseases and pneumonia. In South America, (Ecuador), the use of Dalea species has been reported for stomach ailments treatment. Etnobotanical and ethnopharmacological investigations have been an important source of information that has led to chemical and pharmacological studies in this genus. From chemical studies, the presence of prenyl flavonoids either in North and South American species, appears to be of relevance not only for the interesting pharmacological properties of these compounds but also for their potential as chemotaxonomic markers. Pharmacological evaluations in Dalea species have corroborated their medicinal traditional uses. The antecedents presented in this chapter, denote the chemical richness of flavonoids metabolites present in Dalea, making this genus a vast source for its chemical and pharmacological study.