IODINE INTAKE ADEQUACY AND METABOLIC PARAMETERS IN POLYCYSTIC OVARY SYNDROME PATIENTS

ORTIZ IRINA; ORTIZ GISEL; VELEZ LEANDRO; ALTAMIRANO, J; PELLETAN LEANDRO; MARTINEZ ANTONIO; CARLOS GAMARRA LUQUES,; HAPON M BELEN

Mendoza

Congreso; XL Reunión Científica Anual de la Sociedad de Biología de Cuyo; 2022

Sociedad de Biologia de Cuyo

Polycystic Ovary Syndrome (PCOS) is multifactorial and frequent endocrinopathy in women. On the other hand, hypothyroidism is anendocrinopathy with a high prevalence in women, which impacts female reproduction and metabolism. Despite the high prevalence ofthyroid disease in women with PCOS (10-30%), in our region, there is not a permanent epidemiological surveillance, considering that it isan area of iodine deficiency. Scientific bases confirm that women with PCOS that later became hypothyroid may have adverse outcomeson metabolism and fertility. It is worth to note that, this disorder is aggravated by iodine consumption deficiency which correlates with ahigher prevalence of hypothyroidism. In view of the preceding, this study hypothesized that women with PCOS have a higher prevalenceof metabolic disorders associated to iodine intake. To corroborate this, the goal of this study was to perform a prospective study carried outfrom a cohort of 42 women from 18 to 42 years old (PCOS n=11, Control n=31), who attended for infertility consultation at the Institutode Medicina Reproductiva (IMR) or volunteers from Mendoza province. The presence of PCOS was determined according to the Rotterdamcriteria: oligo-or anovulation, clinical and/or biochemical signs of hyperandrogenism, and/or polycystic ovaries on ultrasound. Thefollowing morphometric parameters were evaluated: age, height and body weight. Besides, the biochemical profile was assessed by theserum determination of total, LDL and HDL cholesterol, triglycerides, glucose, and urine iodine. Statistical analysis was performed bymeans of GraphPad Prism 7 software. The analysis showed that PCOS have a higher body mass index than controls (p=0.0076). Withrespect to the biochemical profile, PCOS patients showed lower levels of total cholesterol (p=0.038) due to the decrease of HDL cholesterol(p=0.0218). The glycemia, triglycerides and LDL cholesterol were not affected. Urine iodine in PCOS women is lower than controls(p=0.027). It is also noteworthy that 27.3% of PCOS patients present iodine insufficiency (