Effect of thyromimetic GC-1 selective signaling on reproductive and lactational performance in the hypothyroid rat

ESTEFANÍA RINALDINI; FIORELLA CAMPO VERDE ARBOCCO; MARCELO EZQUER,; CARLOS GAMARRA LUQUES; MARÍA BELÉN HAPON

European Thyroid Journal

Karger

Año: 2021

2235-0802

Introduction: The potential of thyroid hormone receptor β (TRβ1) selective analog GC-1 has beenwidely proven in animal models and humans. However, its effect on the reproductive stage of thefemale rat has not been evaluated. Methods: the effect of the administration of GC-1 or equimolardoses of triiodothyronine (T3) was evaluated on the reproductive performance of the hypothyroidfemale rat and the indirect effect on pup thyroid status, weight and survival. Results: Hypothyroidismreduced the number of embryos implanted in the uterus, whereas T3 and GC-1 treatment inhypothyroid females reestablished the number of implanted embryos to normal. Initiation of laborwas delayed by hypothyroidism, and T3 replacement treatment reinstated the normal timing ofparturition. The administration of GC-1 alone to the lactating mother did not affect pup survival, weightor thyroidal status. Conclusions: Our findings show the differential effect of thyroid hormone selectivesignaling during gestation and the indirect exposure of the pups; we also emphasize the plausible useof GC-1 for treatment of hypothyroid mothers during the lactation period.