Chapter 7-Multiple functions of Notch signaling during early embryogenesis

LÓPEZ, SILVIA L.

Xenopus, from basic biology to disease models in the genomic era

CRC Press/Taylor and Francis

Año: 2022; p. 77 - 124

Notch signaling is involved in multiple developmental programs across the animal kingdom. This major pathway is typically triggered by cell-cell interactions where the sending cell presents a transmembrane ligand belonging to the Delta/Jagged family. The ligand activates the transmembrane receptor Notch in the receiving cell. Consequently, Notch undergoes enzymatic cleavages, releasing the intracellular domain (NICD). This results in NICD translocation to the nucleus and transcriptional activation of Notch target genes, typically of the HES1-7 and HEY family. More recently, non-canonical Notch activities diverging from the typical signaling device were discovered and are thought to represent ancestral modes of the pathway. This chapter presents a comprehensive review of the expression patterns and experimental functional evidence collected for Notch receptors, ligands, and HES1-7/HEY genes in key processes during early embryogenesis in Xenopus, discussing their involvement in body axis formation, neurogenesis, somitogenesis, development of the germ layers, dorsal midline, and neural plate border-related populations (neural crests and placodes), including aspects of non-canonical signaling. By integrating the dispersed information available, this chapter will help to identify important knowledge gaps, ask new questions, pose new problems, and build in the future gene regulatory networks involving this pathway. https://www.routledge.com/Xenopus-From-Basic-Biology-to-Disease-Models-in-the-Genomic-Era/Fainsod-Moody/p/book/9780367505349