CONTRATADOS
GIRARDI Elena Silvia
artículos
Título:
Area-specific modification of acetylcholinesterase activity following 3-mercaptopropionic acid-induced seizures
Autor/es:
GIRARDI E,SCHNEIDER P Y R LORES ARNAIZ G
Revista:
Molecular and Chemical Neuropathology
Editorial:
Springer Verlag
Referencias:
Lugar: Dusseldorf; Año: 1994 vol. 21 p. 13 - 13
ISSN:
1044-7393
Resumen:
  Abstract Acetylcholinesterase activity (AChE) was assayed in rat CNS membrane fractions after administration of the convulsant 3-mercaptopropionic acid (150 mg/kg, ip). In comparison with saline-injected controls, total AChE activity decreased 12-20% in striatum and cerebellum during seizure and postseizure but failed to change in cerebral cortex. Specific AChE activity, assayed in the presence of 10(-4) M ethopropazine (a butyrylcholinesterase inhibitor), decreased 15-25% in striatum and cerebellum, increased 20-45% in hippocampus, but remained unchanged in cerebral cortex. Saline injection alone increased AChE activity in striatum (68%) and cerebellum (36%) but failed to modify enzyme activity in hippocampus and cerebral cortex. To conclude, AChE sensitivity to convulsant and saline administration is tissue-specific and not restricted to cholinergic areas.
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