GIRARDI Elena Silvia
-"3H-MK801 and3H-NECA binding change after the administration of cyclopentyl adenosine and the convulsant drug 3-mercaptopropionic acid.
LISANDRO GIRALDEZ, FLAVIA ZANETTI AND ELENA GIRARDI.
Lugar: Buenos Aires; Año: 1995 vol. 13 p. 321 - 321
The administration of adenosine receptor agonist CPA before the convulsant MP produces a delay in the appearance of seizures. 3H-NECA binding to striatum adenosine A2 receptors increased afyçter CPA, and CPA 30 minutes before MP were injected (35% and 45% respectively). MP produced and increase of 24% and 15% in 3H-NECA binding in seizure and postseizure period, respectively. 3H-MK801 binding increased after CPA, CPA 30 minutes before MP, MP (seizures stage) and MP (postseizures stage) were administered. A2 adenosine receptors might be involved in an anticonvulsant mechanism, and the CPA administration effect should be due to an neurotoxic action, while the convulsant drug MP produces an overstimulationof NMDAR