INVESTIGADORES
ALONSO Silvia Del Valle
artículos
Título:
Liposome/DNA Systems: Correlation Between Hydrophobicity and DNA Conformational Changes
Autor/es:
N. S. CHIARAMONI ·L. C. BACCARINI · M. C. TAIRA · S. DEL V. ALONSO
Revista:
JOURNAL OF BIOLOGICAL PHYSICS
Editorial:
SPRINGER
Referencias:
Lugar: Europe ; Año: 2008 vol. 34 p. 179 - 188
ISSN:
0092-0606
Resumen:
Abstract In a previous work, we found that liposome hydrophobicity could affect deoxyri-bonucleic acid (DNA) association efficiency. Now, we have focused on the possible cor-relation between liposome hydrophobicity and DNA conformation. DNA lyophilized withcationic vesicles with high hydrophobicity changes its conformation into a more condensedform, probably the C form. With noncharged vesicles, it changes its conformation fromB to a partial A form. These results contribute to a better understanding of the interactionbetween DNA and lipids, suggesting there is direct relationship between hydrophobicity andDNA conformation changes: The higher the hydrophobicity factor, the more pronounced thechanges in DNA form, to a more condensed form.
