Early LPS-induced ERK activation in retinal pigment epithelium cells is dependent on PIP2-PLC

MATEOS, M.V. (AUTOR CORRESPONDIENTE); KAMERBEEK, C.K.; GIUSTO, N.M.; GIUSTO, N.M.; SALVADOR, G.A.

Data in Brief

Elsevier

Año: 2016 p. 423 - 427

2352-3409

This article presents additional data regarding the study ?The phospholipase D pathway mediates the inflammatory response of the retinal pigment epithelium? [1]. The new data presented here show that short exposure of RPE cells to lipopolysaccharide (LPS) induces an early and transient activation of the extracellular signal-regulated kinase (ERK1/2). This early ERK1/2 activation is dependent on phosphatidylinositol bisphosphate-phospholipase C (PIP2-PLC). On the contrary, neither the phospholipase D 1 (PLD1) nor the PLD2 inhibition is able to modulate the early ERK1/2 activation induced by LPS in RPE cells.