INVESTIGADORES
RUMIE VITTAR Natalia Belen
congresos y reuniones científicas
Título:
Photodynamic Therapy modulates a novel pathway in tumor microenvironment mediated by GLI 1.
Autor/es:
VERA RENZO E; MORALES VASCONSUELO BELEN; MARTIN E. FERNANDEZ-ZAPICO; RIVAROLA VIVIANA A; RUMIE VITTAR NATALIA BELEN
Lugar:
Buenos Aires
Reunión:
Congreso; REUNIÓN CONJUNTA DE SOCIEDADES DE BIOCIENCIAS; 2017
Institución organizadora:
SAIC
Resumen:
Tumor microenvironment (TME) is a complex system whose dynamic lead to tumor evolution. In this context, Cancer Associated Fibroblast (CAF) represent stromal cells with ability to promote malignant behavior. This stimulation from TME isregulated by chemokines and transcription factors activity. In this sense, we identify a nones and transcription factors activity. In this sense, we identify a novel axis conformed by GLI and the SDF-1 cytoquine in CAF. Firstly, to mimic TME complexity, we implement a 3D heterotypic co-culture of melanoma cells (SKMel-2) with CAF (F88.2) or tumor cells alone (homotypic spheroids). Onone hand, this 3D cultures showed fibroblast necessity to be well-structured.On the other hand, the cellular migration from heterospheroids is higher than homotypic ones (p
