TUMOR MICROENVIRONMENT TRIGGERS PHO- TODYNAMIC RESISTANCE THROUGH FIBROBLAST POPULATION BY HIF-1 PATHWAY MODULATION

LAMBERTI MARÍA JULIA; JEROEN KRIJGSVELD; RUMIE VITTAR NATALIA BELEN; RIVAROLA VIVIANA A

Mar del Plata

Congreso; LXI REUNIÓN CIENTÍFICA ANUAL Sociedad Argentina de Investigación Clínica; 2016

SAIC

The tumor microenvironment (TME) is a dynamic network that includes the cancer cells, stromal tissue, as well as the extracellular matrix that surrounds it all. Two closely interactive pathways are established in the crosstalk between cancer and fibroblasts, the main stromal cell population: (1) In the "efferent" pathway, cancer cells trigger a reactive response in the stroma, and (2) in the "afferent" pathway, the modified stromal cells in the surrounding microenvironment affect cancer cell responses. Both efferent and afferent pathways are modulated by soluble factors secreted by tumor and stromal cells, which constitute the ?cancer secretome?.