INVESTIGADORES
RUMIE VITTAR Natalia Belen
artículos
Título:
Ecological photodynamic therapy: New trend to disrupt the intricate networks within tumor ecosystem
Autor/es:
N. BELÉN RUMIE VITTAR; MARÍA JULIA LAMBERTI; MARÍA FLORENCIA PANSA; RENZO E. VERA; M. EXEQUIEL RODRIGUEZ; I. SOL COGNO; LAURA N. MILLA SANABRIA; VIVIANA A. RIVAROLA
Revista:
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
Editorial:
ELSEVIER SCIENCE BV
Referencias:
Lugar: Amsterdam; Año: 2013 vol. 1835 p. 86 - 99
ISSN:
0304-419X
Resumen:
Abstract
As with natural ecosystems, species within the tumor
microenvironment are connected by pairwise interactions (e.g.
mutualism, predation) leading to a strong interdependence of different
populations on each other. In this review we have identified the
ecological roles played by each non-neoplastic population (macrophages,
endothelial cells, fibroblasts) and other abiotic components (oxygen,
extracellular matrix) directly involved with neoplastic development. A
way to alter an ecosystem is to affect other species within the
environment that are supporting the growth and survival of the species
of interest, here the tumor cells; thus, some features of ecological
systems could be exploited for cancer therapy. We propose a well-known
antitumor therapy called photodynamic therapy (PDT) as a novel modulator
of ecological interactions. We refer to this as "ecological
photodynamic therapy." The main goal of this new strategy is the
improvement of therapeutic efficiency through the disruption of
ecological networks with the aim of destroying the tumor ecosystem. It
is therefore necessary to identify those interactions from which tumor
cells get benefit and those by which it is impaired, and then design
multitargeted combined photodynamic regimes in order to orchestrate
non-neoplastic populations against their neoplastic counterpart. Thus,
conceiving the tumor as an ecological system opens avenues for novel
approaches on treatment strategies.