INVESTIGADORES
BRACCA Andrea Beatriz Juana
artículos
Título:
Synthesis of tricyclic analogs of stephaoxocanidine and their evaluation as acetylcholinesterase inhibitors
Autor/es:
BIANCHI, DARÍO A.; SCHMEDA HIRSCHMANN, GUILLERMO; THEODULOZ, CRISTINA; BRACCA, ANDREA B. J.; KAUFMAN, TEODORO S.
Revista:
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Editorial:
PERGAMON-ELSEVIER SCIENCE LTD
Referencias:
Lugar: Amsterdam; Año: 2005 vol. 15 p. 2711 - 2715
ISSN:
0960-894X
Resumen:
The synthesis of simplified analogs of the novel isoquinoline alkaloid stephaoxocanidine, carrying the oxazaphenalene ABC-ring system of the natural product, and their activity as inhibitors of the enzyme acetylcholinesterase, are reported. 5,6-Dimethoxy-7H -8-oxa-1-aza-phenalen-9-one (5) was as active as a Narcissus extract enriched in galantamine.
