Phospholipase D signaling modulates the inflammatory response during 6-OH dopamine (6-OHDA)-induced neurotoxicity

IGLESIAS GONZÁLEZ, PABLO A.; GONZÁLEZ-PARDO, VERÓNICA; URANGA, ROMINA MARÍA; SALVADOR, GABRIELA ALEJANDRA

Buenos Aires

Congreso; Reunión Conjunta de Sociedades de Biociencias; 2017

Parkinson?s disease (PD) is the second most common neurodegenerative disorder related with aging. The death of dopaminergic neurons triggered by oxidative stress and mitochondrial dysfunction is one pathognomonic characteristic of PD patients. Neuronal exposure to 6-OH dopamine (6-OHDA), a hydroxylated analogue of dopamine, constitutes a very useful strategy for studying the molecular events associated with neuronal death in PD. Our aim in this study was to characterize the role of phospholipase D (PLD) signaling during 6-OHDA-induced neurotoxicity. The exposure to 6-OHDA (50 and 75 µM) induced an increase in reactive oxygen species (p