Prostanoides y lecho vascular mesentérico: su implicancia en enfermedades cardiometabólicas

LEE HJ; CANTÚ SM; DONOSO AS; CHOI MR; PEREDO H; PUYÓ AM

Ciencia e Investigación

Asociación Argentina para el Progreso de las Ciencias

Lugar: Buenos Aires; Año: 2017 vol. 67 p. 23 - 27

1132-0974

Metabolic diseases such as metabolic syndrome and type 2 diabetes mellitus are closely linked to hypertension and constitute a major public health problem worldwide. However, the exact relationship between them is not yet fully understood. The mesenteric vascular bed constitutes a source of prostanoids such as prostaglandins (PGs) and thromboxanes (TXs). These lipid mediators play an important role in the regulation of vasomotor tone. Recently, the interest in the study of mesenteric bed function in these diseases has been aroused. Alterations in the function of perivascular adipose tissue located in the mesenteric vessels induced by dietary alterations could constitute a possible link between metabolic alterations and the development of cardiovascular diseases such as hypertension. To address these issues, we present the results of a study of our laboratory showing an altered pattern of prostanoid release in the mesenteric vascular bed in an experimental model of metabolic syndrome in rats induced by a high fat diet.