Atrial natriuretic peptide and renal dopaminergic system: a positive friendly relationship?

CHOI MR; RUKAVINA MIKUSIC NL; KOUYOUMDZIAN NM; KRAVETZ MC; FERNÁNDEZ BE

BioMed Research International

Hindawi Pub. Co.

Lugar: New York; Año: 2014 vol. 2014 p. 1 - 10

2314-6133

Sodium metabolism by the kidney is accomplished by an intricate interaction between signals from extrarenal and intrarenal sources and between anti-natriuretic and natriuretic factors. Renal dopamine plays a central role on this interactive network. The natriuretic hormones such as the atrial natriuretic peptide, mediate some of their effects by affecting the renal dopaminergic system. Renal dopaminergic tonus can be modulated at different steps of dopamine metabolism (synthesis, uptake, release, catabolism, receptor sensitization) which can be regulated by the atrial natriuretic peptide. At tubular level, dopamine and atrial natriuretic peptide act together in a concerted manner to promote sodium excretion, especially through the over inhibition of Na+, K+-ATPase activity. In this way, different pathological scenarios where renal sodium excretion is dysregulated, as in nephrotic syndrome or hypertension, are associated with impaired action of renal dopamine and/or atrial natriuretic peptide or as a result of impaired interaction between these two natriuretic systems. The aim of this review is to update and comment the most recent evidences demonstrating how the renal dopaminergic system interact with atrial natriuretic peptide to control renal physiology and blood pressure through different regulatory pathways.