Evaluation of functional polymorphisms associated with the expression of IL-10 as prognostic markers of clinical evolution in individuals chronically infected with Trypanosoma cruzi.

GRIJALVA, ALICIA; TOLEDANO, ANALIA; AGUERO, ROBERTO NICOLAS; DI NARDO, DAVID; BOGDANOVICH, ELIZABETH; REPETTO, HORACIO; STETCHER, DANIEL; REPETTO, SILVIA ANALIA; ALBA SOTO, CATALINA D

Mar del Plata

Congreso; LXI REUNIÓN ANUAL DE LA SOCIEDAD ARGENTINA DE INVESTIGACIÓN CLÍNICA (SAIC); 2016

SOCIEDAD ARGENTINA DE INVESTIGACIÓN CLÍNICA (SAIC)

Chagas disease is a major health issue as 30% of chronically infected individuals will develop cardiac complications. The anti-inflammatory cytokine IL-10 appears to have a role in delaying the onset of chronic chagasic cardiomyopathy (CCC). Low IL-10 levels are a prominent signature of the switch from an anti-inflammatory profile of asymptomatic patients to a proinflammatory one of patients with CCC. The aim of this study was to determine whether a functional polymorphism of the IL-10 promoter (-1082A