IL-10 is required for CD8+ T cell expansion and induction of effector functions during acute Trypanosoma cruzi infection.

MIRANDA, CRISTIAN GABRIEL; PINO-MARTINEZ, AGUSTINA MARIA; BATALLA, ESTELA I; GRIJALVA, ALICIA; GONZALEZ CAPPA, STELLA MARIS; ALBA SOTO, CATALINA D

Mar del Plata

Congreso; Reunión Conjunta 2016 entre la Sociedad Argentina de Investigación Clínica (SAIC), la Sociedad Argentina de Inmunología (SAI) y la Sociedad Argentina de Farmacología Experimental (SAFE),; 2016

Sociedad Argentina de Inmunología (SAI

CD8+ cytotoxic T cells have a central role against intracellular stages of the protozoan Trypanosoma cruzi. While studying the impact of IL-10 on the induction of effector mechanisms, we found that IL-10 deficient (IL-10KO) mice fail to increase the pool of splenic CD8+ T cells (p