INVESTIGADORES
DELPICCOLO Carina Maria Lujan
artículos
Título:
Stereoselective solid-phase synthesis of 3,4-substituted azetidinones as key intermediates for mono-and multicyclic b-lactam antibiotics and enzyme inhibitors
Autor/es:
DELPICCOLO, C. M. L.; MATA, E. G.
Revista:
TETRAHEDRON-ASYMMETRY
Editorial:
PERGAMON-ELSEVIER SCIENCE LTD
Referencias:
Lugar: OXFORD (Inglaterra); Año: 2002 vol. 13 p. 905 - 910
ISSN:
0957-4166
Resumen:
The polymer-supported Staudinger reaction proceeded smoothly under mild conditions to give the corresponding b-lactams in good to high overall yields with excellent cis-selectivity. Upon applying this reaction system, an efficient asymmetric synthesis of b-lactams was accomplished, when chiral acid chlorides or chiral aldehydes were used. These optically active b-lactams would be useful precursors for the generation of combinatorial libraries of potential antibiotics and enzyme inhibitors.
