INVESTIGADORES
DELPICCOLO Carina Maria Lujan
artículos
Título:
Solid-phase synthesis of 2 b-methyl substituted penam derivatives through penicillin sulfoxide rearrangement
Autor/es:
DELPICCOLO, C. M. L.; MATA, E. G.
Revista:
TETRAHEDRON-ASYMMETRY
Editorial:
PERGAMON-ELSEVIER SCIENCE LTD
Referencias:
Lugar: OXFORD (Inglaterra); Año: 1999 vol. 10 p. 3893 - 3897
ISSN:
0957-4166
Resumen:
A new, robust protocol for the solid-phase synthesis of 2b-methyl substituted penam derivatives is described. This synthetic sequence works reliably in good to high overall yields using Merrifield resin as support. The key step involves the thermal rearrangement of the corresponding penicillin sulfoxide.
