Switched LPV Glucose Control in Type 1 Diabetes

PATRICIO COLMEGNA; RICARDO S. SÁNCHEZ PEÑA; RAVI GONDHALEKAR; EYAL DASSAU; FRANK DOYLE III

IEEE TRANSACTIONS ON BIO-MEDICAL ENGINEERING

IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC

Lugar: New York; Año: 2016 vol. 63 p. 1192 - 1200

0018-9294

Objective: The purpose of this work is to regulate the bloodglucose level in Type 1 Diabetes Mellitus (T1DM) patients with apractical and flexible procedure that can switch amongst a finitenumber of distinct controllers, depending on the user?s choice.Methods: A switched Linear Parameter-Varying (LPV) controllerwith multiple switching regions, related to hypo-, hyper-, andeuglycemia situations is designed. The key feature is to arrangethe controller into a framework that provides stability andperformance guarantees. Results: The closed-loop performance istested on the complete in silico adult cohort of the UVA/Padovametabolic simulator, which has been accepted by the U.S. Foodand Drug Administration (FDA) in lieu of animal trials. Theoutcome produces comparable or improved results with respectto previous works. Conclusion: The strategy is practical because itis based on a model tuned only with a priori patient information inorder to cover the interpatient uncertainty. Results confirm that this control structure yields tangible improvements in minimizingrisks of hyper- and hypoglycemia in scenarios with unannouncedmeals. Significance: This flexible procedure opens the possibilityof taking into account, at the design stage, unannounced mealsand/or patients? physical exercise.