INVESTIGADORES
SANCHEZ PEÑA Ricardo Salvador
artículos
Título:
Reducing Risks in Type 1 Diabetes Using H-infinity Control
Autor/es:
PATRICIO COLMEGNA; RICARDO S. SÁNCHEZ PEÑA; RAVI GONDHALEKAR; EYAL DASSAU; FRANK DOYLE III
Revista:
IEEE TRANSACTIONS ON BIO-MEDICAL ENGINEERING
Editorial:
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
Referencias:
Lugar: New York; Año: 2014 vol. 61 p. 2939 - 2947
ISSN:
0018-9294
Resumen:
A control scheme was designed in order to reduce the risks of hyperglycemia and hypoglycemia in Type 1 Diabetes Mellitus (T1DM). This structure is composed of three main components: an H1 robust controller, an Insulin Feedback Loop (IFL) and a Safety Mechanism (SM). A control-relevant model that is employed to design the robust controller is identified. The identification procedure is based on the distribution version of the UVA/Padova metabolic simulator using the simulation adult cohort. The SM prevents dangerous scenarios by acting upon a prediction of future glucose levels, and the IFL modifies the loop gain in order toreduce postprandial hypoglycemia risks. The procedure is tested on the complete in silico adult cohort of the UVA/Padova metabolic simulator, which has been accepted by the Food and Drug Administration (FDA) in lieu of animal trials.
