Antioxidant neolignans from Cordia americana

FERNANDEZ, LUCIA RAQUEL; ADRIANA CIRIGLIANO; MARÍA P. FABANI; BEATRIZ LIMA; SEBASTIÁN ALBERTI; FERNANDO KRAMER; ALEJANDRO A. TAPIA; GABRIELA CABRERA; JORGE A. PALERMO; MARIANELA SÁNCHEZ

PLANTA MEDICA

GEORG THIEME VERLAG KG

Lugar: Stuttgart; Año: 2013 p. 1724 - 1729

0032-0943

Five new neolignans with a bicyclo[2.2.2]octene framework were isolated from an ethanolic extract of the bark of Cordia americana. The structures and relative configurations of the compoundswere elucidated by a combination of spectroscopic methods. All the isolated compounds showed good antioxidant activities in the DPPH radical scavenging (0.5-100 μg/mL) and Ferric-reducing antioxidant power (FRAP, 1-100 μg/mL) assays. One of the compounds displayedmild fungistatic activity at 0.1 μmol/spot against Fusarium virguliforme while, at the same time, all compounds were inactive against several strains of Gram (+) and Gram (-) bacteria at all assayed concentrations (10-1000 μg/mL).