THE PRIMARY CORPORA LUTEA ARE THE MAIN FORCE IN RESTORING THE STEROIDOGENIC CAPACITY IN THE OVARY OF MID-PREGNANT VIZCACHAS (Lagostomus maximus, RODENTIA)

SANTIAGO A CORTASA, SOFÍA PROIETTO, M CLARA CORSO, ALEJANDRO R SCHMIDT, VANINA JAIME, RUTH CWIRENBAUM, PABLO IF INSERRA, ALFREDO D VITULLO, VERÓNICA B DORFMAN; HALPERIN J

Congreso; Reunion Anual de Biociencias 2021; 2021

SAIC, SAI, NANOMED, AAFE

Shortly after beginning the five month-length pregnancy, a natural decline in serum progesterone (P4) triggers reactivation of the hypothalamus-hypophysis-ovary (HHO) axis in vizcachas. Accessory corpora lutea (aCL) developed after this event were proposed as essentials for restoring P4 to the levels required to sustain the gestational process. In this work, we compared the steroidogenic input of primary CL (pCL) vs aCL by histological and morphometric analysis, and by immunohistochemical analysis of the luteinization markers: Star, Cyp19, 3β-HSD, VEGF, FSHR, and LHR in early- (EP), mid- (MP) and term-pregnant females (TP). Non-pregnant ovulated females (NP) were considered as the CL-starting point control group. In EP, the ovaries showed only pCL, whose reactivity levels for the markers mentioned above were significantly lower than those exhibited by the NP group (p