INVESTIGADORES
GARCIA Daniela Celeste
congresos y reuniones científicas
Título:
TYPE I AND TYPE II BMP RECEPTOR EXPRESSION AND SIGNALING IN BOVINE OVIDUCT EPITHELIAL CELLS
Autor/es:
VALDECANTOS, PA; BRAVO MIANA, RC; GARCIA, DANIELA CELESTE; GARCIA, EV; MICELI, DC; ROLDÁN-OLARTE, M
Lugar:
Mar del Plata, Buenos Aires
Reunión:
Congreso; SAIB, 51th Annual Meeting Argentine Society for Biochemistry and Molecular Biology, LI Reunión Anual Sociedad Argentina de Investigación en Bioquímica y Biología Molecular; 2015
Institución organizadora:
Sociedad Argentina de Investigación en Bioquímica y Biología Molecular
Resumen:
Members of the transforming growth factor beta (TGF-β) family, including the bone morphogenetic proteins (BMPs) are expressed in the mammalian oviduct epithelial cells. These signaling molecules play important roles indevelopment and tissues homeostasis; little is known about their function in the oviduct. Modulation of TGF-β/BMP receptor activity is a critical step for signaling regulation. In the present study, RT-qPCR was used to analyze mRNAexpression of BMP receptors type I (BMPR1A, BMPR1B, ACVR1, ACVR1L) and type II (BMPR2, ACVR2A,ACVR2B) in bovine oviduct epithelial cells (BOEC) isolated from ampulla and isthmus at proestrous and diestrous (n=3). Results were statistically analyzed by Student t-test. All of the mRNA BMP receptors were detected in BOEC, except ACVRL1. During diestrous, higher significant mRNA levels were found for BMPR1B, BMPR2 and ACVR2B in isthmus BOEC; and for ACVR2 mRNA in ampulla epithelial cells (p