PERSONAL DE APOYO
BILLORDO Luis Ariel
artículos
Título:
Regulatory and effector T-cells are differentially modulated by Dexamethasone
Autor/es:
JULIETA PANDOLFI; PLÁCIDA BAZ; PABLO FERNÁNDEZ; AILÉN DISCIANNI LUPI; FLORENCIA PAYASLIÁN; LUIS ARIEL BILLORDO; LEONARDO FAINBOIM; LOURDES ARRUVITO
Revista:
CLINICAL IMMUNOLOGY
Editorial:
ACADEMIC PRESS INC ELSEVIER SCIENCE
Referencias:
Lugar: Amsterdam; Año: 2013 p. 400 - 410
ISSN:
1521-6616
Resumen:
It is assumed that the ratio between effector T cells (Teff) and regulatory T cells
(Tregs) controls the immune reactivity within the T-cell compartment. The purpose of this study
was to investigate if Dexamethasone (Dex) affects Teff and Tregs subsets. Dex induced on Tregs a
dose and time-dependent apoptosis which resulted in a relative increase of Teff. After TCR
activation, Dex induced a strong proliferative inhibition of Teff, but a weaker proliferative inhibition
on Tregs. These effects were modulated by IL-2, which not only restored the proliferative response,
but also prevented Dex-induced apoptosis. The highest dose of IL-2 prevented apoptosis on all
FOXP3 + CD4+ T cells. Meanwhile, the lowest dose only rescued activated Tregs (aTregs), probably
related to their CD25 higher expression. Because Dex did not affect the suppressor capacity of aTregs
either, our results support the notion that under Dex treatment, the regulatory T-cell compartment
maintains its homeostasis.