Montmorrilonite K10 catalyzed efficient synthesis of some 4'-nitrochalcones and their 1, 3, 5-triaryl-2-pyrazolines and in vitro antimicrobial evaluation

K. L. AMETA; NITU S. RATHOREA; MAYA KUMARIA; PRIYANKA KHYALIYA; R. R. DANGI; EDUARDO A. PARELLADA; ADRIANA NESKE

IranJOC Iranian Journal of Organic Chemistry

Islamic Azad University Of Qaemshahr

Lugar: Qaemshahr; Año: 2016 vol. 8 p. 1833 - 1844

2008-3599

Abstract: An expeditious synthesis of some 4´-nitrochalcones (3a-n) and their subsequent facile one-pot transformation to 1, 3,5-triaryl-2-pyrazolines (4a-n) has been carried out using montmorrilonite K10 via microwave mediated solvent free protocol.An emphasis is given to highlighting the greenness of the processes, and a fair comparison is also provided between differentinorganic solid supports as catalysts. Both conventional as well as non-conventional approaches have been explored bycomparing the reaction conditions and yields. The newly synthesized pyrazolines were studied for their in vitro antimicrobialevaluation against bacterial strains Bacillus pumilus and Escherichia coli and fungal strains Aspergillus niger and Penicilliumchrysogenum. Findings of biological evaluation highlighted 4b, 4e, 4j and 4m as potential new leads in the search of newantimicrobial agents. The structures of newly synthesized compounds have been established on the basis of elemental analysisand spectroscopic studies.