INVESTIGADORES
BERMUDEZ Jose Maria
congresos y reuniones científicas
Título:
Development of an injectable in situ modified release system for veterinary use: Poloxamer and Polyelectrolytes platforms of release
Autor/es:
JOSÉ M. BERMUDEZ; RICARDO GRAU; JUAN CARLO GOTTIFREDI
Lugar:
Rosario
Reunión:
Taller; 1º Taller de Órganos Artificiales, Biomateriales e Ingeniería de Tejidos (BIOOMAT). Sociedad Latinoamericana de Biomateriales, Ingeniería de Tejidos y Órganos Artificiales (SLABO).; 2009
Resumen:
The aim of the present work it is to explore the potential of combining
Poloxamer 407 (PO) and polyelectrolytes (PE) as an in situ injectable release system for veterinary use, using
Progesterone (Prg) as model drug, and evaluating the release and erosion from
the developed formulations. PO, Carragenina (CA), Alginic Acid (AA), Sodium Carboxy methyl
cellulose
(CM) and Prg were used to prepare the evaluated formulations. To obtain in vitro release profiles; the membraneless
model was used at 38 ± 0.05 ºC, with 10 mL of physiological solution as release
medium. At
predetermined intervals
of time,
the release medium was completely replaced by new one, which was supported at
38 ± 0.05 ºC. It was determining the weight of the formulations to calculate
the proportion of dissolved gel. Prg's
release rate is influenced by different ways, according to the PE incorporated
in the release platform of PO-Prg. For example, when the gear incorporates CM
it increases about a 20%. Whereas the
aggregate of AA practically does not influence (3%) and CA's presence decreases
the release rate in about 10%. It is noticed that in all the evaluated systems
the erosion increases in with the incorporation of the macromolecules in the
following order CM ˃AA ˃CA. These results are coincidental with the data of
release obtained. PE's incorporation influences significantly in the release
and erosion of PO-Prg systems, allowing to select formulations with in vitro optimal properties for the development
of an injectable in situ delivery
system for veterinary medicine use.