Loss of tristetraprolin (TTP) promotes development of dysplastic lesions in tongue epithelium.

STEDILE MICAELA; FERRI DARÍO; VEGGETTI MARIELA; KORDON EDITH; RAIMONDI ANA

Mar del Plata

Congreso; LXI Reunión Anual de SAIC, LXIV Reunión Anual de SAI, XLVIII Reunión Anual de SAFE, VII Reunión Anual de NANOMEDAR, V Congreso Nacional de AACYTAL; 2016

immunohistochemistry.During the evaluation period (8 months) mice were healthy. However, we found a significant decrease in transgenic mice weight compared with wild type mice (p< 0, 01). Histologic analysis of TTP-KO tongues revealed moderate dysplastic areas which exhibited chronic inflammation with infiltrated macrophages and increased vascularization. Immunohistochemistry of epithelial TTP ? KO tongue showed an abnormal expression of PCNA (proliferation marker) and deregulated expression of cytokeratins 1, 6 and 14 (differentiation markers). Particularly, PCNA and cytokeratin 14 were found in suprabasal layers, which are typically expressed in the basal layer of normal tissue. We conclude that lack of TTP is sufficient to deregulate proliferation and differentiation in tongue epithelium and contributes to progressive accumulation of dysplastic changes.