Social Interaction and Memory are affected by Chronic Administration of Fluoxetine in 5-HT2aR Knockout Mice

SACSON AGOSTINA; MORICI FACUNDO; BEKINSCHTEIN, PEDRO; NOELIA V WEISSTAUB

COrdoba

Congreso; COngreso anual de la Sociedad argentina de investigaciones en neurociencias; 2018

SAN

Fluoxetine(FLX) is a selective serotonin reuptake inhibitor, well known for its antidepressanteffects and for being widely prescribed in the treatment of differentpsychiatric disorders. We intended to analyze if chronic administration of FLXpresented cognitive effects and the possible role of 5-HT2aR in those effects.For this purpose, we administrated a chronic oral dose of fluoxetine (10mg/kg)to Wild Type (WT) and 5-HT2aR knockout mice (KO). After 4 weeks of FLXadministration, we performed a novel object recognition task and a socialinteraction test.  The results showedthat a 3 min training session is not enough to generate a long term NOR memory (24h delayed) independently of the genotype. Interestingly, FLX treatment allowedWT mice to solve the NOR test. However, we didn´t see this effect in KO mice.Regarding social interaction, FLX improved the performance of the WT mice butnot the KO. These results suggest that 5HT2A signaling might be involve in theeffects of fluoxetine in memory and social interaction in mice.