Activity regulated cytoskeleton-associated protein is required for consolidati

MAGDALENA MIRANDA; FACUNDO MORICI; GALLO FRANCISCO; DINKA PIROMALLI GIRADO; NOELIA V WEISSTAUB; BEKINSCHTEIN, PEDRO

Mar del Plata

Congreso; XXXII Reunion ANual de; 2017

SAN

Successful memory involves not only remembering information over time but also keeping memories distinct and less confusable. The ability to separate the components of memories into distinct memory representations relies on pattern separation, a computational process by which differences are amplified. Pattern separation has been investigated in the dentate gyrus of the hippocampus and shown to occur in a spatial domain (DG), but little is known about this process in other brain regions like the perirhinal cortex (Prh) that process a different type of information (ie. non-spatial object memories). In this work, we used a PRH-dependent task and manipulated the load of pattern separation during information encoding. We showed in male rats that consolidation of pattern-separated object memories (and not spatial memories) depends on the expression of the gene Arc is required in the PRH for separable storage of overlapping, but not distinct, object representations, and also the neurotrophin BDNF is required for this pattern separation process, which is identical to its role in the DG., and that interaction between Arc and the neurotrophin BDNF is necessary for successful pattern separation. We provide novel evidence regarding the proteins involved in pattern separation outside the DG and suggest that, despite the anatomical differences, similar mechanisms underlie pattern separation in the DG and Prh that are engaged depending exclusively on the similarity of the stimuli.