IL-17 EFFECT ON TUMOR PROGRESSION MAY DEPEND ON PARTICULAR IL-17 RECEPTORS SUBUNIT EXPRESSION ON TUMOR CELLS AND EFFECTS ON ANTITUMOR IMMUNITY

RODRIGUEZ C; ARAUJO FURLÁN CL; BOCCARDO S; BOSSIO SN; TOSELLO BOARI J; CANALE, FP; BECCARIA CG; GRUPPI A; MONTES CL; ACOSTA RODRIGUEZ EV

Congreso; REUNIÓN DE SOCIEDADES DE BIOCIENCIAS 2020; 2020

The role of IL-17 signaling in the tumor progression is controversial.Several reports indicate that IL-17 sustain, directly and indirectly,tumor growth and immune-escape. However, IL-17also supportsanti-tumoral immunity by potentiating CD8+ T and NK cell responses. Our aim is to determine the role of IL-17-signaling in tumor progression dissecting pro- and anti-tumoral effects. First, we evaluated IL-17 receptor (IL-17Rs) expression in melanoma (B16-SIY) andthymoma (EL4-SIY) tumor cells. While both cells expressed variedamounts of IL-17RA and IL-17RD transcripts, IL-17RC was detected only in B16-SIY. According to the different IL-17Rs expressionprofiles, exposure to IL-17A in vitro resulted in different outcomes.B16-SIY showed an increase in the amounts of transcripts encodingpro-inflammatory mediators (VEGF, HIF1a and N-cadherin, p