Galectin-3 regulates germinal centers formation, autoreactive and long-lived antibody response

BECCARIA CG; AMEZCUA VESELY MC; FIOCCA VERNENGO F; GOROSITO SERRÁN M; RAMELLO MC; TOSELLO BOARI J; MUCCI J; CAMPETELLA O; MONTES CL; ACOSTA RODRIGUEZ EV; GRUPPI A

Congreso; LVII Reunión Anual de la Sociedad Argentina de Inmunología; 2014

We previously observed that B cells undergoing differentiation to antibody-secreting cells (ASC) downregulate the expression of Gal3 and that inhibition increases terminal B cell differentiation. In agreement, we observed that Gal3 knock-out (KO) mice showed a higher frequency of IgM and IgG ASC (p