EXHAUSTED T CELLS (TIM-3+PD-1+) INFILTRATE TUMORS OF 4T1 MAMMARY CARCINOMA BEARING MICE.

CANALE F; RAMELLO MC; TOSELLO BOARI J; ARAUJO FURLÁN CL; GOROSITO SERRÁN M; ACOSTA RODRIGUEZ EV; MONTES CL

Congreso; First Argentinean Spring Course in Advance Immunology and LXI Reunión Anual de la Sociedad Argentina de Inmunología.; 2013

T cell exhaustion is a state of T cell dysfunction that arises during chronic infections and cancer. It is defined by poor effector functions, sustained expression of inhibitory receptors like PD-1 and Tim-3 and different transcriptional signatures. We investigated this cell population in blood, tumor, lymph node and lung of 4T1 mammary carcinoma bearing mice. We observed that 29 days post tumor cells injection (pti) higher frequency of CD4+ than CD8+ T-cells (p