Evaluation of the role of tissue repair regulatory T cells during acute Trypanosoma cruzi infection.

BOCCARDO S; ARAUJO FURLÁN CL; C RODRIGUEZ, CP ABRATE, L ALMADA; GRUPPI A; MONTES CL; ACOSTA RODRIGUEZ EV

Congreso; Reunión Conjunta SAIC.SAI.SAFIS.; 2022

T. cruzi (Tc) and the type I response required to control it promotedamage in target tissues. Tissue repair regulatory Foxp3+ CD4+T cells (trTreg) are defined as ST2+ KLRG-1+ and specialized inmaintaining tissue homeostasis and favoring repair upon injury inaddition to their immunoregulatory properties. We aimed to studytrTregs role in damage control during acute Tc infection. To this end,Foxp3-GFP C57BL/6 mice were infected (INF) with 5000 Tc parasites(Tulahuen). Skeletal muscle, liver and spleen (Sp) infiltrate wasevaluated by flow cytometry in a kinetic study. trTregs were reducedin all tissues at 21 days post infection (dpi) in correlation with maximumtissue damage and parasitism, and decreased systemic levelsof their growth factor IL33 (p