Dynamics of soluble immune mediators in covid-19 patients from an argentinean cohort with moderate and severe symptoms.

ALMADA L*, ANGIOLINI S*, DHO N*, DUTTO J*, GAZZONI Y*, MANZONE C*, MARÍN *; PONCE NE, IRIBARREN P, CERBÁN F, MORÓN G, AMEZCUA VESELY C, ANA Y, CERVI L, CHIAPELLO L, FOZZATTI L, ICELY P, MACCIONI M, MENA C, MONTES CL, MOTRÁN CC, RODRÍGUEZ GALÁN C, STEMPIN C, ; VIANO ME, BERTONE M, ABIEGA C, ESCUDERO E, KAHN A, CAEIRO JP, ARROYO F, MALETTO B; ACOSTA RODRÍGUEZ EV,; GRUPPI A, SOTOMAYOR CE.

Congreso; Reunión Conjunta SAIC.SAI.AAFE.NANOMED.Ar.; 2021

The cytokine storm, a form of systemic inflammatory response syndrome, is one of themost dreadful complications that can occur during COVID-19. In this work, we aimed atstudying the occurrence of a cytokine storm in a cohort of COVID-19 patients (Cpts) fromCórdoba (Argentine). During first wave, we collected sera from individuals with RT-PCR+for SARS-CoV2 hospitalized in Hospital Privado with moderate (MOD) and severe (SEV)disease (n=62, aged 21-80 years) as well as healthy controls (HC n=24, age matched),to determine the concentrations of IL-1, IL-6, IL-8, IL-10, IL-12, IL-28A/B, IL-29, TNF,IP-10, IFN, IFN, IFNand GM-CSF by LEGENDplexTM. Males represented 74% ofMOD and 67% of SEV Cpts. Hypertension (HT, 48%), obesity (31%), dyslipidemia (DL,24%), and diabetes (24%) were the most frequent comorbidities. All cytokines, exceptIL-28A/B, were significantly increased in total Cpts in comparison with HC (p