Phenotypic and functional characterization of peripheral T cell populations from COVID-19 patients hospitalized in Hospital Privado Universitario Córdoba- Argentina.

L ONOFRIO*, J DUTTO*, S BOSSIO*, RE BAIGORRI*, MB BRUGO*; L ALMADA**, C MARÍN**, F RUIZ MORENO**, X VOLPINI**, ; M ALMEIDA, C OLIVERA, N PONCE, JN QUIROZ, S SILVERA RUIZ, L BOFELLI, ; ACOSTA RODRIGUEZ EV; C AMEZCUA VESELY, D ARROYO, F CERBÁN, L CERVI, L FOZZATTI, P ICELY, P IRIBARREN, B MALETTO, G MORÓN, C RODRÍGUEZ GALÁN, C STEMPIN, C ABIEGA#, D ESCUDERO#, A KAHN#, JP CAEIRO#, M MACCIONI, C MOTRÁN, L CHIAPELLO, C MONTES, A GRUPPI,; CE SOTOMAYOR

Congreso; Reunión Conjunta SAIC.SAI.AAFE.NANOMED.Ar.; 2021

SARS-CoV-2 infection results in asymptomatic, mild or severe disease. T cells couldcontribute to these different outcomes, but it remains unclear whether T cell response isdysfunctional or excessive. Here, we evaluated the phenotypic and functional featuresof circulating T cells from a cohort of 40 COVID-19 patients (Cpts) with moderate (MOD)and severe (SEV) clinical disease (aged 21- 80 years) and 14 aged matched healthycontrols (HC) by FACS. All Cpts exhibited a reduced frequency of CD3+T and Tregscells compare to HC (p< 0.05). When exhaustion was evaluated, SEV Cpts showedhigher % of PD-1+ and CD39+ in T conv cells (p