INVESTIGADORES
ACOSTA RODRIGUEZ Eva Virginia
artículos
Título:
Depletion of immature B cells during Trypanosoma cruzi infection: involvement of myeloid cells and cyclooxigenase pathway
Autor/es:
ZUÑIGA EI; ACOSTA RODRIGUEZ EV; MERINO MC; MONTES CL; GRUPPI A
Revista:
EUROPEAN JOURNAL OF IMMUNOLOGY
Referencias:
Año: 2005 p. 1849 - 1858
ISSN:
0014-2980
Resumen:
The ability of a microorganism to elicit or evade B cell responses represents a
determinant factor for the final outcome of an infection. Although pathogens may
subvert humoral responses at different stages of B cell development, most studies
addressing the impact of an infection on the B cell compartment have focused on
mature B cells within peripheral lymphoid organs. Herein, we report that a protozoan
infection, i.e. a Trypanosoma cruzi infection, induces a marked loss of immature B cells
in the BM, which also compromises recently emigrated B cells in the periphery. The
depletion of BM immature B cells is associated with an increased rate of apoptosis
mediated by a parasite-indirect mechanism in a Fas/FasL-independent fashion. Finally,
we demonstrated that myeloid cells play an important role in B cell depletion, since
CD11b+ BM cells from infected mice secrete a product of the cyclooxygenase pathway
that eliminates immature B cells. These results highlight a previously unrecognized
maneuver used by a protozoan parasite to disable B cell generation, limiting host
defense and favoring its chronic establishment.i.e. a Trypanosoma cruzi infection, induces a marked loss of immature B cells
in the BM, which also compromises recently emigrated B cells in the periphery. The
depletion of BM immature B cells is associated with an increased rate of apoptosis
mediated by a parasite-indirect mechanism in a Fas/FasL-independent fashion. Finally,
we demonstrated that myeloid cells play an important role in B cell depletion, since
CD11b+ BM cells from infected mice secrete a product of the cyclooxygenase pathway
that eliminates immature B cells. These results highlight a previously unrecognized
maneuver used by a protozoan parasite to disable B cell generation, limiting host
defense and favoring its chronic establishment.+ BM cells from infected mice secrete a product of the cyclooxygenase pathway
that eliminates immature B cells. These results highlight a previously unrecognized
maneuver used by a protozoan parasite to disable B cell generation, limiting host
defense and favoring its chronic establishment.