INVESTIGADORES
ACOSTA RODRIGUEZ Eva Virginia
artículos
Título:
A Trypanosoma cruzi antigen signals CD11b+ cells to secrete cytokines that promote polyclonal B cell proliferation and differentiation into antibody secreting cells
Autor/es:
MONTES CL; ACOSTA RODRIGUEZ EV; MUCCI J; ZUÑIGA EI; CAMPETELLA O; GRUPPI A
Revista:
EUROPEAN JOURNAL OF IMMUNOLOGY
Referencias:
Año: 2006 p. 1474 - 1485
ISSN:
0014-2980
Resumen:
Microbial-induced polyclonal activation of B cells is a common event in several forms of
infections, and is believed to play a crucial role both for enhancing the production of
specific antibodies and for maintenance of B cell memory. Therefore, a major challenge
in biomedical research is the identification of pathogen-derived products capable of
rapidly mounting B cell expansion and differentiation. Here we report that glutamate
dehydrogenase (GDH) stimulates polyclonal proliferation and differentiation of naive B
cells. This stimulation was found to be T cell independent, but to absolutely require
CD11b+ cells. Moreover, we demonstrate that stimulation of CD11b+ cells by GDH leads
to the production of IL-6, IL-10 and B cell-activating factor (BAFF), all of which combine
to powerfully induce B cell expansion. Importantly, IL-6 and IL-10 further drive B cell
terminal differentiation into plasma cells by up-regulating critical transcription factors
and immunoglobulin secretion. Our data provide the first evidence that a protozoan
antigen can induce BAFF production by accessory cells, which in concert with other
cytokines trigger polyclonal B cell activation.
to the production of IL-6, IL-10 and B cell-activating factor (BAFF), all of which combine
to powerfully induce B cell expansion. Importantly, IL-6 and IL-10 further drive B cell
terminal differentiation into plasma cells by up-regulating critical transcription factors
and immunoglobulin secretion. Our data provide the first evidence that a protozoan
antigen can induce BAFF production by accessory cells, which in concert with other
cytokines trigger polyclonal B cell activation.
to the production of IL-6, IL-10 and B cell-activating factor (BAFF), all of which combine
to powerfully induce B cell expansion. Importantly, IL-6 and IL-10 further drive B cell
terminal differentiation into plasma cells by up-regulating critical transcription factors
and immunoglobulin secretion. Our data provide the first evidence that a protozoan
antigen can induce BAFF production by accessory cells, which in concert with other
cytokines trigger polyclonal B cell activation.
to the production of IL-6, IL-10 and B cell-activating factor (BAFF), all of which combine
to powerfully induce B cell expansion. Importantly, IL-6 and IL-10 further drive B cell
terminal differentiation into plasma cells by up-regulating critical transcription factors
and immunoglobulin secretion. Our data provide the first evidence that a protozoan
antigen can induce BAFF production by accessory cells, which in concert with other
cytokines trigger polyclonal B cell activation.
to the production of IL-6, IL-10 and B cell-activating factor (BAFF), all of which combine
to powerfully induce B cell expansion. Importantly, IL-6 and IL-10 further drive B cell
terminal differentiation into plasma cells by up-regulating critical transcription factors
and immunoglobulin secretion. Our data provide the first evidence that a protozoan
antigen can induce BAFF production by accessory cells, which in concert with other
cytokines trigger polyclonal B cell activation.
to the production of IL-6, IL-10 and B cell-activating factor (BAFF), all of which combine
to powerfully induce B cell expansion. Importantly, IL-6 and IL-10 further drive B cell
terminal differentiation into plasma cells by up-regulating critical transcription factors
and immunoglobulin secretion. Our data provide the first evidence that a protozoan
antigen can induce BAFF production by accessory cells, which in concert with other
cytokines trigger polyclonal B cell activation.
to the production of IL-6, IL-10 and B cell-activating factor (BAFF), all of which combine
to powerfully induce B cell expansion. Importantly, IL-6 and IL-10 further drive B cell
terminal differentiation into plasma cells by up-regulating critical transcription factors
and immunoglobulin secretion. Our data provide the first evidence that a protozoan
antigen can induce BAFF production by accessory cells, which in concert with other
cytokines trigger polyclonal B cell activation.
to the production of IL-6, IL-10 and B cell-activating factor (BAFF), all of which combine
to powerfully induce B cell expansion. Importantly, IL-6 and IL-10 further drive B cell
terminal differentiation into plasma cells by up-regulating critical transcription factors
and immunoglobulin secretion. Our data provide the first evidence that a protozoan
antigen can induce BAFF production by accessory cells, which in concert with other
cytokines trigger polyclonal B cell activation.
+ cells. Moreover, we demonstrate that stimulation of CD11b+ cells by GDH leads
to the production of IL-6, IL-10 and B cell-activating factor (BAFF), all of which combine
to powerfully induce B cell expansion. Importantly, IL-6 and IL-10 further drive B cell
terminal differentiation into plasma cells by up-regulating critical transcription factors
and immunoglobulin secretion. Our data provide the first evidence that a protozoan
antigen can induce BAFF production by accessory cells, which in concert with other
cytokines trigger polyclonal B cell activation.