Immune mediators against Toxoplasma gondii during reactivation of toxoplasmic retinochoroiditis

MARCELO RUDZINSKI; CARINA ARGÜELLES; CRISTÓBAL COUTO; JOSÉ R. OUBIÑA; SILVIA REINA

OCULAR IMMUNOLOGY AND INFLAMMATION

Taylos and Francis Group

Lugar: London; Año: 2019 vol. 27 p. 949 - 957

0927-3948

Purpose: To analyze possible associations between systemic and ocular cytokine levels andspecific clinical ophthalmologic signs from patients with a reactivation of toxoplasmicretinochoroiditis (RTR). Methods: eighteen patients with an active RTR episode, eight patientswith inactive scars and 14 control patients were included in the study. Serum samples andAqueous humor samples were analyzed for IFN-γ, IL-10 and IL-6 levels by ELISA.Inflammation grade, location and size of the retinochoroideal active lesion, sampling time andtime to resolution were recorded. Results: a significantly negative correlation between AH andserum levels of IFN-γ was detected (p