TRAINING AND IMPLEMENTATION OF A RECONSTRUCTED HUMAN EPIDERMIS (RHE) MODEL TO EVALUATE SKIN IRRITATION IN ARGENTINA

ROCO, JULIETA; LENZE, MARIELA; BENEDETTI, MARTINA; RODRIGO DE VECCHI; GUTIÉRREZ, MARÍA LAURA

Niagara Falls

Congreso; 12th World Congress on Alternatives and Animal Use in the Life Sciences; 2023

Alternative Congress Trust

The implementation of alternative methods to the use of animals for regulatory purposesin Argentina is incipient. Although there are still no restrictions at the regulatory level,social pressure and advances in regulatory matters in other countries have led to theneed for non-animal methodologies for the evaluation of cosmetic products. Faced withthe global trend of replacement, the first Alternative Methods Laboratory (LMA-EBAL)was created in Argentina with the purpose of implementing, developing and training invitro methodologies. In this sense, we organized the first hands-on workshop ofSkinEthic™ OECD TG 439 for Skin Irritation Test in the country. The training wasministered by Rodrigo De Vecchi and María Laura Gutiérrez; it was attended byregulators and specialists from the National Administration of Medicines, Food andMedical Technology (ANMAT), from the ANLIS Malbrán Institute, CONICET researchers,professors from the UBA, from the pharmaceutical and cosmetic industry, testlaboratories and representatives of the Argentine Chamber of the Cosmetic andPerfumery Industry (CAPA).In the first implementation of the methodology in the LMA-EBAL, the skin irritationpotential produced by 14 AIN VEGAN cosmetic products was assessed according to theOECD TG439 guideline. The success of this experience is important for Argentina sincethe training was very popular and the implementation allowed testing the SkinEthicimport system from Episkin Brazil.