INVESTIGADORES
PELLEGRINI Gretel Gisela
congresos y reuniones científicas
Título:
BODY COMPOSITION AND BONE MARKERS IN WISTAR AND OBESE (Ò) GROWING RATS, FED THE RECOMMENDED DIETARY CALCIUM CONTENT
Autor/es:
MAROTTE C; WEISSTAUB A; HERNANDEZ E; GONZALES CHAVES MMS; PELLEGRINI GG; PORTELA ML; ZENI SN
Lugar:
Estados Unidos
Reunión:
Congreso; American Society for Bone and Mineral Research 31th Annual Meeting; 2009
Institución organizadora:
ASBMR
Resumen:
Interrelationship between osteoporosis and obesity has been recently described. Therefore, the objective was to compare the effect of feeding a normal calcium diet on body weight and composition and its relation to bone markers levels in Wistar (W) and genetically modified obese (bO) rats during growth.
Female W and bO adult rats were mated and fed during pregnancy and lactation diets prepared according to AIN´93 recommendations. At weanling, male pups continued feeding the same diet ad libitum till 50 days of age. Food consumption and body weight (BW) were recorded 3times/week. At the end of the experience body composition (AOAC methods), bone alkaline phosphatase (bAP), osteocalcine (BGP) and C-telopeptide of type 1 collagen (CTX) (ELISA) were determined. Results (mean± SD) were:
W (n=11)
bG (n=11)
p
Body water (g/100 g)
64.0 ± 4.6
59.7 ± 2,8
0.02
Body protein (g/100 g)
19.7 ± 2.9
14.9 ± 1.7
0.0012
Body ashes (g/100 g)
3.2 ± 0.4
2.4 ± 0.2
0.0001
Body fat (g/100 g)
10.0 ± 1.7
12.7 ± 3.1
0.0368
bAP (IU/L)
68 ± 10
193 ± 39
<0.0001
BGP (UI/L)
841 ± 106
386 ± 40
<0.0001
SCTX
94 ± 6
65 ± 9
<0.0001
There were no statistical differences in food intake neither in BW. Body composition results indicate an increase in lipogenesis and a decrease in bone ashes content, although there was no differences in the dietary calcium intake. Moreover, the lower BGP and CTX activity in bG would suggest an imbalance in bone metabolism because of a reduction in bone mineralization and bone resorption in spite of the increase in bAP, which reflects the osteoblastic differentiation.
Conclusions: These results suggest that the etiology of obesity and osteoporosis should have a biochemical common mechanism. UBACYT (2008-10) B 091.