Histomorphometrical comparison of three different bone grafts: deproteinized bovine bone, bio-glass and, synthetic hydroxyapatite.

PELLEGRINI MA; GONZALES CHAVES MMS; ORZUZA R; ZENI SN; PELLEGRINI GG

Congreso; 45th European Calcified Tissue Society Congress; 2018

ECTS

Bone graft implantation is required to guide bone repair. Deproteinized bovine bone putty (BB), bioglass (BG) and, synthetic hydroxyapatite (SH) are frequently indicated as bone grafting materials due to their osteoconductive properties. We compared the bone healing response of BB, BG and SH (Synergy, Odontit Implant Systems, Argentina) in a critical sized bone defect. We created a bone defect of 4 mm diameter in rat tibiae for implantation with each biomaterial (N=30 rats). Samples were collected at 2 and 4 weeks for histological and histomorphometrical analysis of new bone formation (NBF) and remaining particles of each device (RP). Results: Percentage of NBF (mean ± SD): 2 weeks: Control group: 6.60±3.71; BB group: 23.23±3.89*; BG group: 18.35±5.23*; SH group: 26.27±9.30*; 4 weeks: Control group: 6.69±2.38; BB group: 24.37±3.66*; BG group: 17.45±6.64*; SH group: 32.25±3.80*. Percentage of RP: 2 weeks: Control group: 0±0; BB group: 5.04±1.39*; BG group: 3.03±2.31*; SH group: 4.46±2.87*; 4 weeks: Control group: 0±0; BB group: 4.45±2.35*; BG group: 2.87±1.14*; SH group: 3.78±1.68* (*p