INVESTIGADORES
PELLEGRINI Gretel Gisela
artículos
Título:
Correlation between salivary and serum markers of bone turnover in osteopenic rats.
Autor/es:
PELLEGRINI GRETEL G; GONZALES CHAVES MS; SOMOZA JULIA C; FRIEDMAN SILVIA M; ZENI SUSANA NOEMI
Revista:
JOURNAL OF PERIODONTOLOGY
Editorial:
American Academy of Periodontology
Referencias:
Lugar: USA; Año: 2008 vol. 79 p. 158 - 165
ISSN:
0022-3492
Resumen:
Background: Previously, we measured bone alkaline phosphatase
(b-ALP) and terminal C-telopeptide of collagen type I
(CTX) in saliva. The present longitudinal experimental study
sought to determine whether salivary concentrations of b-ALP
and CTX have the same response as in serum samples under
different conditions: normal, increased, and reduced bone remodeling.
(b-ALP) and terminal C-telopeptide of collagen type I
(CTX) in saliva. The present longitudinal experimental study
sought to determine whether salivary concentrations of b-ALP
and CTX have the same response as in serum samples under
different conditions: normal, increased, and reduced bone remodeling.
(b-ALP) and terminal C-telopeptide of collagen type I
(CTX) in saliva. The present longitudinal experimental study
sought to determine whether salivary concentrations of b-ALP
and CTX have the same response as in serum samples under
different conditions: normal, increased, and reduced bone remodeling.
(b-ALP) and terminal C-telopeptide of collagen type I
(CTX) in saliva. The present longitudinal experimental study
sought to determine whether salivary concentrations of b-ALP
and CTX have the same response as in serum samples under
different conditions: normal, increased, and reduced bone remodeling.
Previously, we measured bone alkaline phosphatase
(b-ALP) and terminal C-telopeptide of collagen type I
(CTX) in saliva. The present longitudinal experimental study
sought to determine whether salivary concentrations of b-ALP
and CTX have the same response as in serum samples under
different conditions: normal, increased, and reduced bone remodeling.
Methods: Thirty rats were ovariectomized (OVX) to induce
osteopenia 60 days after surgery, and 10 rats were sham operated.
Then, the ratswere divided into four groups and treated
as follows for 45 days: group 1 (G1) = SHAM+ vehicle; group 2
(G2) = OVX + 8 mg olpadronate (OPD)/100 g of body weight;
group 3 (G3) = OVX + 4 mg OPD/100 g of body weight; and
group 4 (G4) = OVX + vehicle. Saliva and serum CTX and
b-ALP were determined at 60 days (baseline) and at 75 days
(T75). Lumbar spine and proximal tibia bone mineral density
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
b-ALP were determined at 60 days (baseline) and at 75 days
(T75). Lumbar spine and proximal tibia bone mineral density
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
b-ALP were determined at 60 days (baseline) and at 75 days
(T75). Lumbar spine and proximal tibia bone mineral density
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
b-ALP were determined at 60 days (baseline) and at 75 days
(T75). Lumbar spine and proximal tibia bone mineral density
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
group 4 (G4) = OVX + vehicle. Saliva and serum CTX and
b-ALP were determined at 60 days (baseline) and at 75 days
(T75). Lumbar spine and proximal tibia bone mineral density
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
b-ALP were determined at 60 days (baseline) and at 75 days
(T75). Lumbar spine and proximal tibia bone mineral density
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
b-ALP were determined at 60 days (baseline) and at 75 days
(T75). Lumbar spine and proximal tibia bone mineral density
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
b-ALP were determined at 60 days (baseline) and at 75 days
(T75). Lumbar spine and proximal tibia bone mineral density
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
group 4 (G4) = OVX + vehicle. Saliva and serum CTX and
b-ALP were determined at 60 days (baseline) and at 75 days
(T75). Lumbar spine and proximal tibia bone mineral density
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
b-ALP were determined at 60 days (baseline) and at 75 days
(T75). Lumbar spine and proximal tibia bone mineral density
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
b-ALP were determined at 60 days (baseline) and at 75 days
(T75). Lumbar spine and proximal tibia bone mineral density
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
b-ALP were determined at 60 days (baseline) and at 75 days
(T75). Lumbar spine and proximal tibia bone mineral density
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
group 4 (G4) = OVX + vehicle. Saliva and serum CTX and
b-ALP were determined at 60 days (baseline) and at 75 days
(T75). Lumbar spine and proximal tibia bone mineral density
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
b-ALP were determined at 60 days (baseline) and at 75 days
(T75). Lumbar spine and proximal tibia bone mineral density
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
b-ALP were determined at 60 days (baseline) and at 75 days
(T75). Lumbar spine and proximal tibia bone mineral density
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
b-ALP were determined at 60 days (baseline) and at 75 days
(T75). Lumbar spine and proximal tibia bone mineral density
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
group 3 (G3) = OVX + 4 mg OPD/100 g of body weight; and
group 4 (G4) = OVX + vehicle. Saliva and serum CTX and
b-ALP were determined at 60 days (baseline) and at 75 days
(T75). Lumbar spine and proximal tibia bone mineral density
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
b-ALP were determined at 60 days (baseline) and at 75 days
(T75). Lumbar spine and proximal tibia bone mineral density
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
b-ALP were determined at 60 days (baseline) and at 75 days
(T75). Lumbar spine and proximal tibia bone mineral density
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
b-ALP were determined at 60 days (baseline) and at 75 days
(T75). Lumbar spine and proximal tibia bone mineral density
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
group 4 (G4) = OVX + vehicle. Saliva and serum CTX and
b-ALP were determined at 60 days (baseline) and at 75 days
(T75). Lumbar spine and proximal tibia bone mineral density
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
b-ALP were determined at 60 days (baseline) and at 75 days
(T75). Lumbar spine and proximal tibia bone mineral density
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
b-ALP were determined at 60 days (baseline) and at 75 days
(T75). Lumbar spine and proximal tibia bone mineral density
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
b-ALP were determined at 60 days (baseline) and at 75 days
(T75). Lumbar spine and proximal tibia bone mineral density
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
group 4 (G4) = OVX + vehicle. Saliva and serum CTX and
b-ALP were determined at 60 days (baseline) and at 75 days
(T75). Lumbar spine and proximal tibia bone mineral density
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
b-ALP were determined at 60 days (baseline) and at 75 days
(T75). Lumbar spine and proximal tibia bone mineral density
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
b-ALP were determined at 60 days (baseline) and at 75 days
(T75). Lumbar spine and proximal tibia bone mineral density
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
b-ALP were determined at 60 days (baseline) and at 75 days
(T75). Lumbar spine and proximal tibia bone mineral density
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
group 4 (G4) = OVX + vehicle. Saliva and serum CTX and
b-ALP were determined at 60 days (baseline) and at 75 days
(T75). Lumbar spine and proximal tibia bone mineral density
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
b-ALP were determined at 60 days (baseline) and at 75 days
(T75). Lumbar spine and proximal tibia bone mineral density
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
b-ALP were determined at 60 days (baseline) and at 75 days
(T75). Lumbar spine and proximal tibia bone mineral density
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
b-ALP were determined at 60 days (baseline) and at 75 days
(T75). Lumbar spine and proximal tibia bone mineral density
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
group 3 (G3) = OVX + 4 mg OPD/100 g of body weight; and
group 4 (G4) = OVX + vehicle. Saliva and serum CTX and
b-ALP were determined at 60 days (baseline) and at 75 days
(T75). Lumbar spine and proximal tibia bone mineral density
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
b-ALP were determined at 60 days (baseline) and at 75 days
(T75). Lumbar spine and proximal tibia bone mineral density
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
b-ALP were determined at 60 days (baseline) and at 75 days
(T75). Lumbar spine and proximal tibia bone mineral density
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
b-ALP were determined at 60 days (baseline) and at 75 days
(T75). Lumbar spine and proximal tibia bone mineral density
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
group 4 (G4) = OVX + vehicle. Saliva and serum CTX and
b-ALP were determined at 60 days (baseline) and at 75 days
(T75). Lumbar spine and proximal tibia bone mineral density
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
b-ALP were determined at 60 days (baseline) and at 75 days
(T75). Lumbar spine and proximal tibia bone mineral density
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
b-ALP were determined at 60 days (baseline) and at 75 days
(T75). Lumbar spine and proximal tibia bone mineral density
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
b-ALP were determined at 60 days (baseline) and at 75 days
(T75). Lumbar spine and proximal tibia bone mineral density
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
group 4 (G4) = OVX + vehicle. Saliva and serum CTX and
b-ALP were determined at 60 days (baseline) and at 75 days
(T75). Lumbar spine and proximal tibia bone mineral density
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
b-ALP were determined at 60 days (baseline) and at 75 days
(T75). Lumbar spine and proximal tibia bone mineral density
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
b-ALP were determined at 60 days (baseline) and at 75 days
(T75). Lumbar spine and proximal tibia bone mineral density
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
b-ALP were determined at 60 days (baseline) and at 75 days
(T75). Lumbar spine and proximal tibia bone mineral density
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
group 4 (G4) = OVX + vehicle. Saliva and serum CTX and
b-ALP were determined at 60 days (baseline) and at 75 days
(T75). Lumbar spine and proximal tibia bone mineral density
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
b-ALP were determined at 60 days (baseline) and at 75 days
(T75). Lumbar spine and proximal tibia bone mineral density
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
b-ALP were determined at 60 days (baseline) and at 75 days
(T75). Lumbar spine and proximal tibia bone mineral density
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
b-ALP were determined at 60 days (baseline) and at 75 days
(T75). Lumbar spine and proximal tibia bone mineral density
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
group 3 (G3) = OVX + 4 mg OPD/100 g of body weight; and
group 4 (G4) = OVX + vehicle. Saliva and serum CTX and
b-ALP were determined at 60 days (baseline) and at 75 days
(T75). Lumbar spine and proximal tibia bone mineral density
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
b-ALP were determined at 60 days (baseline) and at 75 days
(T75). Lumbar spine and proximal tibia bone mineral density
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
b-ALP were determined at 60 days (baseline) and at 75 days
(T75). Lumbar spine and proximal tibia bone mineral density
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
b-ALP were determined at 60 days (baseline) and at 75 days
(T75). Lumbar spine and proximal tibia bone mineral density
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
group 4 (G4) = OVX + vehicle. Saliva and serum CTX and
b-ALP were determined at 60 days (baseline) and at 75 days
(T75). Lumbar spine and proximal tibia bone mineral density
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
b-ALP were determined at 60 days (baseline) and at 75 days
(T75). Lumbar spine and proximal tibia bone mineral density
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
b-ALP were determined at 60 days (baseline) and at 75 days
(T75). Lumbar spine and proximal tibia bone mineral density
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
b-ALP were determined at 60 days (baseline) and at 75 days
(T75). Lumbar spine and proximal tibia bone mineral density
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
group 4 (G4) = OVX + vehicle. Saliva and serum CTX and
b-ALP were determined at 60 days (baseline) and at 75 days
(T75). Lumbar spine and proximal tibia bone mineral density
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
b-ALP were determined at 60 days (baseline) and at 75 days
(T75). Lumbar spine and proximal tibia bone mineral density
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
b-ALP were determined at 60 days (baseline) and at 75 days
(T75). Lumbar spine and proximal tibia bone mineral density
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
b-ALP were determined at 60 days (baseline) and at 75 days
(T75). Lumbar spine and proximal tibia bone mineral density
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
group 4 (G4) = OVX + vehicle. Saliva and serum CTX and
b-ALP were determined at 60 days (baseline) and at 75 days
(T75). Lumbar spine and proximal tibia bone mineral density
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
b-ALP were determined at 60 days (baseline) and at 75 days
(T75). Lumbar spine and proximal tibia bone mineral density
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
b-ALP were determined at 60 days (baseline) and at 75 days
(T75). Lumbar spine and proximal tibia bone mineral density
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
b-ALP were determined at 60 days (baseline) and at 75 days
(T75). Lumbar spine and proximal tibia bone mineral density
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(G2) = OVX + 8 mg olpadronate (OPD)/100 g of body weight;
group 3 (G3) = OVX + 4 mg OPD/100 g of body weight; and
group 4 (G4) = OVX + vehicle. Saliva and serum CTX and
b-ALP were determined at 60 days (baseline) and at 75 days
(T75). Lumbar spine and proximal tibia bone mineral density
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
b-ALP were determined at 60 days (baseline) and at 75 days
(T75). Lumbar spine and proximal tibia bone mineral density
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
b-ALP were determined at 60 days (baseline) and at 75 days
(T75). Lumbar spine and proximal tibia bone mineral density
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
b-ALP were determined at 60 days (baseline) and at 75 days
(T75). Lumbar spine and proximal tibia bone mineral density
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
group 4 (G4) = OVX + vehicle. Saliva and serum CTX and
b-ALP were determined at 60 days (baseline) and at 75 days
(T75). Lumbar spine and proximal tibia bone mineral density
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
b-ALP were determined at 60 days (baseline) and at 75 days
(T75). Lumbar spine and proximal tibia bone mineral density
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at baseline and at 105 days.
(BMD) was determined using dual-energy x-ray absorptiometry
at